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Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

National Institutes of Health Nonprofit eligible

Administered by National Institutes of Health, this health grant invites applications from nonprofits and other eligible applicants, with applications due Jul 1, 2028. It provides awards up to $300K–$5M.

Apply on Grants.gov
Deadline
Jul 1, 2028
Award amount
Up to $300K–$5M
Posted
Jun 25, 2026
Opportunity number
PAR-27-022
CFDA
93.310, 93.351, 93.855, 93.859, 93.866, 93.867

Opportunity description

This Notice of Funding Opportunity (NOFO) announces the restructured Shared Instrumentation Grant (SIG) Program that consolidates three existing shared-use instrumentation programs, i.e., the Shared Instrumentation Grant program, the High-End Instrumentation Grant program, and the Basic Instrumentation Grant program. The NOFO invites applications from groups of NIH-supported investigators to purchase or upgrade a single state-of-the-art commercially available instrument or an integrated instrumentation system. The instruments purchased through the SIG Program are required to be optimally shared among the users to ensure efficient and cost-effective research operations, enable rigorous and reproducible measurements, and encourage collaborative research and benefit broad research communities at large. The minimum award is $300,000. There is no cap on the total cost of the instrument; however, the maximum award is $5,000,000. Cost sharing is required for premium instruments or special use instruments.

Who can apply

  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Public and State controlled institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • City or township governments
  • Special district governments
  • County governments
  • Small businesses
  • State governments
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • For profit organizations other than small businesses
  • Public housing authorities/Indian housing authorities
  • Private institutions of higher education
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Funding

Award floor
$300K
Award ceiling
$5M

Agency contact

National Institutes of Health

Office of Research Infrastructure Programs (ORIP) odsig@mail.nih.gov

odsig@mail.nih.gov

Where to apply

Submission is handled entirely on Grants.gov. Open the official listing below to see the full notice, required forms, and the authoritative deadline.

Official Grants.gov listing

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