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Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

National Institutes of Health Nonprofit eligible

Looking for health funding? National Institutes of Health is accepting applications for this award from nonprofits and other eligible applicants, with applications due Mar 5, 2027.

Open the official Grants.gov listing
Deadline
Mar 5, 2027
Posted
May 4, 2026
Opportunity number
PAR-27-081
CFDA
93.242, 93.279, 93.866, 93.867

Opportunity description

The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.

Who can apply

  • Public housing authorities/Indian housing authorities
  • State governments
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • Public and State controlled institutions of higher education
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Independent school districts
  • Small businesses
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Private institutions of higher education
  • Native American tribal governments (Federally recognized)
  • City or township governments
  • Special district governments
  • For profit organizations other than small businesses
  • County governments

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Agency contact

National Institutes of Health

National Institute on Aging (NIA) NIA-NOFO-Scientific@nih.gov

NIA-NOFO-Scientific@nih.gov

How to apply

You will apply through Grants.gov, the federal grants portal. Confirm every detail — eligibility, attachments, and the deadline — on the official page before you commit time to it.

Official Grants.gov listing

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