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Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)

National Institutes of Health Nonprofit eligible

Administered by National Institutes of Health, this health grant invites applications from nonprofits and other eligible applicants, with applications due Nov 5, 2027. It provides awards up to $1.5M.

View & apply on Grants.gov
Deadline
Nov 5, 2027
Award amount
Up to $1.5M
Posted
Dec 4, 2024
Opportunity number
PAR-25-297
CFDA
93.866

Opportunity description

The goal of this Notice of Funding Opportunity (NOFO) is to provide funding support for the pre-clinical and early stage clinical (Phase I) development of novel small-molecule and biologic drug candidates that prevent Alzheimer's disease (AD), slow its progression, or treat its cognitive and behavioral symptoms. Participants in this program will receive funding for therapy development activities such as medicinal chemistry; pharmacokinetics (PK); Absorption, Distribution, Metabolism, Excretion, Toxicology (ADMET); efficacy in animal models; development of biomarkers for target engagement; formulation development; chemical synthesis under Good Manufacturing Practices (GMP); Investigational New Drug (IND) enabling studies; and initial Phase I clinical testing. Applications not responsive to this NOFO include research on basic mechanisms of disease or mechanisms of drug action; development ofrisk, diagnostic, prognostic, predictive, and preventionbiomarkers, devices, non-pharmacological interventions (e.g., exercise, diet, cognitive training), repurposed drugs and combination therapies; discovery activities such as high-throughput screening and hit optimization; and stand-alone clinical trials.

Who can apply

  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Independent school districts
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • State governments
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Special district governments
  • Native American tribal governments (Federally recognized)
  • For profit organizations other than small businesses
  • County governments
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • City or township governments
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Funding

Award ceiling
$1.5M

Agency contact

National Institutes of Health

NIH Grants Information grantsinfo@nih.gov

grantsinfo@nih.gov

Where to apply

Applications go through Grants.gov directly. We recommend reading the full announcement and double-checking eligibility and dates on the official listing first.

Official Grants.gov listing

This listing is sourced from the public Grants.gov database (U.S. government public-domain data) and is provided for general informational purposes. VolunteerBadge is not affiliated with Grants.gov or any federal agency and does not administer or award grants. Always verify details on the official listing.

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