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Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)

National Institutes of Health Nonprofit eligible

Administered by National Institutes of Health, this health grant invites applications from nonprofits and other eligible applicants, with applications due Oct 11, 2026.

Open the official Grants.gov listing
Deadline
Oct 11, 2026
Expected awards
5
Posted
Apr 29, 2026
Opportunity number
RFA-MH-27-135
CFDA
93.242, 93.279

Opportunity description

The purpose of this notice of funding opportunity (NOFO) is to elucidate the key components of the therapeutic effects of rapid-acting psychotropic interventional drugs (RAPIDs) by addressing the methodological challenges involved with these clinical trials. In addition, this NOFO seeks to advance understanding of how RAPIDs and adjunctive psychosocial interventions can be optimally delivered, monitored, and sustained over time to enhance effectiveness and generalizability. The NOFO will support studies designed to enhance the rigor of RAPID clinical trial design, which will ultimately increase the interpretability of the data and the generalizability of the results.

Who can apply

  • Small businesses
  • Public housing authorities/Indian housing authorities
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • State governments
  • County governments
  • Public and State controlled institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Special district governments
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • For profit organizations other than small businesses
  • City or township governments
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Private institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Agency contact

National Institutes of Health

Division of Translational Research DTRcommunications@nih.gov

DTRcommunications@nih.gov

Where to apply

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Official Grants.gov listing

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