DoW Amyotrophic Lateral Sclerosis Research Program, Clinical Outcomes and Biomarkers Award
This open federal grant from Jamie Shortall Grant Officer supports science & technology-focused work and is available to eligible applicants, with applications due Sep 30, 2026.
Open the official Grants.gov listingOpportunity description
Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Clinical Outcomes and Biomarkers Award (COBA) supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical trials in amyotrophic lateral sclerosis (ALS). Projects can be relevant to a specific therapy, a class of therapeutics, or to a specific ALS subtype (such as a particular genetic mutation) and do not have to broadly apply to all patients.
Distinctive Features: To meet the intent of the funding opportunity, applications may address clinical biomarkers and/or clinical outcomes. This may include the identification, development, and/or validation of promising biomarkers for ALS, which may include, but are not limited to susceptibility/risk, diagnostic, monitoring/disease progression, prognostic, predictive, response, or safety biomarkers. Clinical Outcomes projects may focus on the identification, development, and/or validation of clinician-, observer-, or patient-reported, and/or performance outcome measures for ALS. Projects may include the optimization of current outcome measures already in use.
Applications may utilize digital health measures, including wearable devices, smart-phone sensors, video or voice recordings, imaging studies, or other devices which record disease-relevant physiological data and/or outcomes.
Community Collaboration is an important element of the FY26 ALSRP COBA. Applicants will be expected to articulate how the proposed research question or study design was informed by the
ALS lived experience community.
Who can apply
- Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
Agency contact
Jamie Shortall Grant Officer
eBRAP Help Desk Phone: 301-682-5507 Email: help@eBRAP.org
help@eBRAP.orgWhere to apply
Applications go through Grants.gov directly. We recommend reading the full announcement and double-checking eligibility and dates on the official listing first.
Official Grants.gov listingInformation here comes from the public Grants.gov dataset, which is U.S. government public-domain data, and is shared for general guidance only. VolunteerBadge neither administers grants nor speaks for any agency — confirm everything on the official listing before applying.