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INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

National Institutes of Health Nonprofit eligible

National Institutes of Health is funding health projects through this opportunity, which is open to nonprofits and other eligible applicants, with applications due Jun 15, 2028. It provides awards up to $500K.

Open the official Grants.gov listing
Deadline
Jun 15, 2028
Award amount
Up to $500K
Expected awards
4
Posted
May 12, 2026
Opportunity number
RFA-OD-27-004
CFDA
93.121, 93.173, 93.233, 93.242, 93.310, 93.350, 93.351, 93.395, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.855, 93.865, 93.866, 93.867, 93.879

Opportunity description

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Who can apply

  • City or township governments
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • For profit organizations other than small businesses
  • Native American tribal governments (Federally recognized)
  • Independent school districts
  • Small businesses
  • State governments
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Special district governments
  • Public housing authorities/Indian housing authorities
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • County governments
  • Public and State controlled institutions of higher education
  • Native American tribal organizations (other than Federally recognized tribal governments)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Funding

Award ceiling
$500K

Agency contact

National Institutes of Health

The INCLUDE Project DownSyndromeINCLUDE@mail.nih.gov

DownSyndromeINCLUDE@mail.nih.gov

Next steps to apply

This award is administered through the federal Grants.gov system. Review the complete instructions and verify the deadline on the official page before starting your submission.

Official Grants.gov listing

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