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GREGoRi Innovation Projects (U01 Clinical Trial Optional)

National Institutes of Health Nonprofit eligible

This open federal grant from National Institutes of Health supports health-focused work and is available to nonprofits and other eligible applicants, with applications due Oct 30, 2026. It provides awards up to $3–$500K.

See full details on Grants.gov
Deadline
Oct 30, 2026
Award amount
Up to $3–$500K
Expected awards
10
Posted
Jun 18, 2026
Opportunity number
RFA-HG-27-013
CFDA
93.172

Opportunity description

The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.

Who can apply

  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • State governments
  • Special district governments
  • For profit organizations other than small businesses
  • Small businesses
  • City or township governments
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Public and State controlled institutions of higher education
  • County governments
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • Native American tribal governments (Federally recognized)
  • Independent school districts
  • Private institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Funding

Award floor
$3
Award ceiling
$500K

Agency contact

National Institutes of Health

GREGoRi Program Team nhgri-gregor@mail.nih.gov

nhgri-gregor@mail.nih.gov

Where to apply

Applications go through Grants.gov directly. We recommend reading the full announcement and double-checking eligibility and dates on the official listing first.

Official Grants.gov listing

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