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Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

National Institutes of Health Nonprofit eligible

This open federal grant from National Institutes of Health supports education-focused work and is available to nonprofits and other eligible applicants, with applications due Aug 21, 2028. It provides awards up to $3M.

View & apply on Grants.gov
Deadline
Aug 21, 2028
Award amount
Up to $3M
Posted
Sep 10, 2025
Opportunity number
PAR-25-446
CFDA
93.279

Opportunity description

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

Who can apply

  • Public and State controlled institutions of higher education
  • State governments
  • Special district governments
  • Native American tribal governments (Federally recognized)
  • For profit organizations other than small businesses
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Private institutions of higher education
  • City or township governments
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • Independent school districts
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Small businesses
  • County governments

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Funding

Award ceiling
$3M

Agency contact

National Institutes of Health

NIH Grants Information grantsinfo@nih.gov

grantsinfo@nih.gov

Where to apply

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Official Grants.gov listing

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