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Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)

National Institutes of Health Nonprofit eligible

National Institutes of Health is funding health projects through this opportunity, which is open to nonprofits and other eligible applicants, with applications due Jul 5, 2029. It provides awards up to $500K.

Apply on Grants.gov
Deadline
Jul 5, 2029
Award amount
Up to $500K
Posted
Jun 4, 2026
Opportunity number
PAR-27-057
CFDA
93.121

Opportunity description

This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that individually, sequentially, or in combination trigger human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses also are encouraged.

Who can apply

  • County governments
  • State governments
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • Special district governments
  • City or township governments
  • Public housing authorities/Indian housing authorities
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Small businesses
  • Public and State controlled institutions of higher education
  • For profit organizations other than small businesses
  • Native American tribal governments (Federally recognized)
  • Private institutions of higher education
  • Independent school districts
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Funding

Award ceiling
$500K

Agency contact

National Institutes of Health

National Institute of Dental and Craniofacial Research (NIDCR) deeranotifications@nidcr.nih.gov

deeranotifications@nidcr.nih.gov

Next steps to apply

You will apply through Grants.gov, the federal grants portal. Confirm every detail — eligibility, attachments, and the deadline — on the official page before you commit time to it.

Official Grants.gov listing

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