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Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)

National Institutes of Health Nonprofit eligible

Administered by National Institutes of Health, this health grant invites applications from nonprofits and other eligible applicants, with applications due Nov 10, 2026. It provides awards up to $300K.

Apply on Grants.gov
Deadline
Nov 10, 2026
Award amount
Up to $300K
Expected awards
13
Posted
Jun 3, 2026
Opportunity number
RFA-CA-27-002
CFDA
93.394

Opportunity description

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites grant applications proposing exploratory research projects focused on further development and technical validation of emerging technologies offering novel capabilities for the molecular or cellular characterization of cancer or for improved handling and quality control of biospecimens used for basic, clinical, or epidemiological cancer research. This NOFO solicits R33 applications where major feasibility gaps for the technology or methodology have been overcome, as demonstrated with supportive preliminary data, but still require further development and rigorous technical validation to encourage adoption by the research community. Well-suited applications must propose the development of technologies that offer the potential to accelerate and/or enhance research in the areas of cancer biology, early detection and screening, clinical diagnosis, treatment, cancer control, epidemiology. Technologies proposed for development may have potential for widespread applicability but must be focused in this proposal on cancer-relevant use cases. Projects proposing to apply or use existing technologies for hypothesis-driven research where the novelty resides in the biological or clinical target/question being pursued are not responsive to this solicitation and will not be reviewed.This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.

Who can apply

  • Independent school districts
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • City or township governments
  • Public housing authorities/Indian housing authorities
  • Special district governments
  • County governments
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Public and State controlled institutions of higher education
  • Small businesses
  • State governments
  • Private institutions of higher education
  • For profit organizations other than small businesses
  • Native American tribal governments (Federally recognized)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Funding

Award ceiling
$300K

Agency contact

National Institutes of Health

National Cancer Institute (NCI) NCI-IMAT@nih.gov

NCI-IMAT@nih.gov

Applying for this grant

Submission is handled entirely on Grants.gov. Open the official listing below to see the full notice, required forms, and the authoritative deadline.

Official Grants.gov listing

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