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HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Clinical Trial Center and Clinical Centers (U01 Clinical Trial Optional)

National Institutes of Health Nonprofit eligible

National Institutes of Health has posted this health grant for nonprofits and other eligible applicants, with applications due Jul 9, 2026. It provides awards up to $500K.

View & apply on Grants.gov
Deadline
Jul 9, 2026
Award amount
Up to $500K
Expected awards
8
Posted
May 19, 2026
Opportunity number
RFA-HL-27-008
CFDA
93.837

Opportunity description

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including master protocol development, project management, recruitment oversight, performance milestones, and scientific conduct of trials. The CCs will recruit and retain heart failure patients and controls. The CCs will participate in all aspects of conducting a deep phenotyping protocol and longitudinal follow-up of HFpEF patients; obtaining tissue biopsies; and recruiting patients for future clinical trials.Eligible applicants may submit proposals for either the CTC or CC, but must have different PIs. Each application should include CTC or CC as part of their project title.Companion NOFO for RFA-HL-27-009 will support a Data Translation Center (DTC) for overall coordination of the HeartShare program.

Who can apply

  • Public and State controlled institutions of higher education
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • Native American tribal governments (Federally recognized)
  • Public housing authorities/Indian housing authorities
  • Independent school districts
  • Special district governments
  • State governments
  • For profit organizations other than small businesses
  • Small businesses
  • Private institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • City or township governments
  • County governments
  • Native American tribal organizations (other than Federally recognized tribal governments)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Funding

Award ceiling
$500K

Agency contact

National Institutes of Health

Division of Cardiovascular Sciences, HeartShare Team nhlbiheartshare@mail.nih.gov

nhlbiheartshare@mail.nih.gov

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