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HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)

National Institutes of Health Nonprofit eligible

National Institutes of Health has posted this health grant for nonprofits and other eligible applicants, with applications due Feb 20, 2029.

Apply on Grants.gov
Deadline
Feb 20, 2029
Expected awards
3
Posted
Jun 16, 2026
Opportunity number
RFA-NS-27-007
CFDA
93.213, 93.233, 93.273, 93.279, 93.395, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865, 93.866, 93.867

Opportunity description

The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process. The scope of the program includes lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, and Phase I clinical testing. This is a milestone-driven, phased cooperative agreement program that involves active participation by NIH program staff in project planning and ongoing monitoring of research progress.

Who can apply

  • Native American tribal governments (Federally recognized)
  • Public housing authorities/Indian housing authorities
  • For profit organizations other than small businesses
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • State governments
  • City or township governments
  • Independent school districts
  • Private institutions of higher education
  • Special district governments
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Small businesses
  • County governments
  • Public and State controlled institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Agency contact

National Institutes of Health

National Institute of Neurological Disorders and Stroke (NINDS) PTDP@ninds.nih.gov

PTDP@ninds.nih.gov

Where to apply

Submission is handled entirely on Grants.gov. Open the official listing below to see the full notice, required forms, and the authoritative deadline.

Official Grants.gov listing

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