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Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

National Institutes of Health Nonprofit eligible

National Institutes of Health has posted this health grant for nonprofits and other eligible applicants, with applications due Feb 17, 2028.

Go to the Grants.gov listing
Deadline
Feb 17, 2028
Posted
Jun 17, 2025
Opportunity number
PAR-25-442
CFDA
93.121, 93.242, 93.350, 93.855, 93.865, 93.867

Opportunity description

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.

Who can apply

  • Native American tribal organizations (other than Federally recognized tribal governments)
  • City or township governments
  • Special district governments
  • Independent school districts
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • For profit organizations other than small businesses
  • State governments
  • Small businesses
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • Private institutions of higher education
  • Native American tribal governments (Federally recognized)
  • Public housing authorities/Indian housing authorities
  • County governments
  • Public and State controlled institutions of higher education

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Agency contact

National Institutes of Health

NIH Grants Information grantsinfo@nih.gov

grantsinfo@nih.gov

Ready to apply?

Applications go through Grants.gov directly. We recommend reading the full announcement and double-checking eligibility and dates on the official listing first.

Official Grants.gov listing

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